Demi Moore’s new movie, “The Substance,” which opens Sept. 20, is a dark comedy about the horrors of getting older as a woman in Hollywood. But it’s also a literal body-horror film — the basic premise is that Moore’s character, an aging actress-turned-celebrity-fitness-instructor named Elisabeth Sparkle, takes a strange elixir (the substance) that allows her to create a younger, more perfect version of herself. And you see that creation in bloody, visceral detail. The movie kind of grossed me out, to be honest, but I couldn’t stop thinking about it afterward. And it was fascinating to see Moore, who has been open about her own struggles with her body image and has lived most of her life in the public eye, play this role.

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I’ve been mesmerized by Moore for decades, starting in 1985 with “St. Elmo’s Fire,” when her husky voice and bold onscreen persona — in this instance, a kind of wildness that made her seem both alluring and destructive — first broke through. There was a period when it felt as if every movie Moore starred in was an event — “Ghost,” “A Few Good Men,” “G.I. Jane,” “Striptease,” “Indecent Proposal.” She eventually became the highest-paid actress in Hollywood, and also an early advocate for pay equity in the industry, long before the issue was part of the national discourse.

But even though Moore was such a visible celebrity of my teenage and early adult years, I never felt I knew much about her until reading her revealing 2019 memoir, “Inside Out,” which opens at the lowest point in her life, with the end of her marriage to Ashton Kutcher and her relapse into alcoholism. Moore’s struggles started early as the child of a mentally ill, alcoholic mother. But much of the book is about the extreme lengths she went to during her prime Hollywood days to control her body through disordered eating and exercise. Now in her 60s and a grandmother, Moore tells me she has finally grown comfortable in her own skin and, with “The Substance” and this stage of her career, is hoping to upend expectations about what it means to be an aging woman in an industry that both embraced and judged her harshly. (And a note: I asked Moore how her former husband Bruce Willis, who’s living with frontotemporal dementia, is doing, and she said he’s stable and OK, all things considered.)

Why did you sign on to star in a movie about a woman who’s aging in Hollywood and at war with her own body? It felt very meta watching you do this. Why it was easy for me to step in and do this is because I don’t feel I am her. This is a woman who has no family — she’s dedicated her entire life to her career, and when that’s taken, what does she have? And so, in a way, I had enough separation from her, and at the same time, a deep, internal connection to the pain that she was experiencing, the rejection that she felt. I knew it would be challenging, but potentially a really important exploration of the issue.

Tell me what you understand the issue to be. That it’s not about what’s being done to us — it’s what we do to ourselves. It’s the violence we have against ourselves. The lack of love and self-acceptance, and that within the story, we have this male perspective of the idealized woman that I feel we as women have bought into.

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